文献类型：期刊文献

英文题名：MiR-320a is Downregulated in Patients with Myasthenia Gravis and Modulates Inflammatory Cytokines Production by Targeting Mitogen-activated Protein Kinase 1

作者：Cheng, Zhuoan[1,2];Qiu, Shaobo[3];Jiang, Lin[1,2];Zhang, Anle[1,2];Bao, Wenjing[4];Liu, Ping[3];Liu, Jianwen[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[3]Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China;[4]Liaoning Univ Tradit Chinese Med, China Affiliated Hosp, Liaoning 110032, Peoples R China

年份：2013

卷号：33

期号：3

起止页码：567

外文期刊名：JOURNAL OF CLINICAL IMMUNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000323123700008)】；

基金：This work was supported by Shanghai Science and Technology Commission (No. 10JC1414500) and the Shanghai Committee of Science and Technology [grant 11DZ2260600].

语种：英文

外文关键词：Myasthenia gravis; miR-320a; MAPK1; cytokine; COX-2

摘要：Myasthenia gravis (MG) are T-cell dependent antibody-mediated autoimmune disorders, microRNAs are important regulators of human autoimmune disease pathogenesis. Here, we investigated the miRNAs expression profiles in MG for the first time and found that miR-320a was significantly downregulated in MG patients compared to normal healthy people. Meanwhile, pro-inflammatory cytokins in MG patients were overexpressed. Furthermore, we identified MAPK1 as a direct target of miR-320a. Downregulation of miR-320a induced the overexpression of pro-inflammatory cytokins through promoting COX-2 expression. This process was modulated by ERK/NF-kappa B pathways. Taken together, our findings suggested that miR-320a could play a role in modulation of inflammatory cytokins production.