文献类型：期刊文献

英文题名：Fine-Tuning the Colors of Natural Pigment Emodin with Superior Stability through Cocrystal Engineering

作者：Li, Meiqi[1,2];Zhang, Zhen[1,3];Zhang, Qi[1];Peng, Bo[1];Zhu, Bin[4];Wang, Jian-rong[1];Liu, Liyu[1,2];Mei, Xuefeng[1]

机构：[1]Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China;[2]Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;[3]Nanchang Univ, Coll Pharm, Nanchang 330006, Jiangxi, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Lab Pharmaceut Crystal Engn & Technol, Shanghai 200237, Peoples R China

年份：2018

卷号：18

期号：10

起止页码：6123

外文期刊名：CRYSTAL GROWTH & DESIGN

收录：;EI(收录号：20183905858910);WOS:【SCI-EXPANDED(收录号:WOS:000446923500048)】；

基金：This research work was financially supported by the Shanghai Natural Science Foundation (Grant No. 18ZR1447900), the Youth Innovation Promotion Association CAS (Grant No. 2016257), CAS Key Technology Talent Program, and SANOFI-SIBS Scholarship.

语种：英文

外文关键词：Chemical stability - Charge transfer - Chemical modification

摘要：Due to the increasing concern of toxicity when using synthetic pigments, naturally occurring materials have regained attention. However, the limited hues and instability restrict their applications. Emodin (EM) is considered as a naturally sourced pigment and has been added in chemic necessities for many years. In this work, continuous color changes can be achieved by careful selection of coformers via a cocrystal engineering approach. This fine color tuning could be attributed to the different pi-pi and charge-transfer interactions after cocrystal formation. Furthermore, EM cocrystals were found to have superior stability in formulations. Fine color modifications and better stability behaviors in cocrystals may provide a new pathway to develop naturally sourced pigments without chemical synthesis.