文献类型：期刊文献

英文题名：A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications

作者：He, Haihong[1];Xia, Yang[1];Qi, Yingxue[1];Wang, Hong-Yin[5];Wang, Zhuang[1];Bao, Jianming[7];Zhang, Ziqian[6];Wu, Fu-Gen[5];Wang, Haolu[2];Chen, Daijie[4];Yang, Dahai[1];Liang, Xiaowen[2];Chen, Jinquan[3];Zhou, Shengmin[1];Liang, Xin[1];Qian, Xuhong[1];Yang, Youjun[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn,Sch Pharm, Shanghai 200237, Peoples R China;[2]Univ Queensland, Diamantina Inst, Translat Res Inst, Therapeut Res Ctr, Woolloongabba, Qld 4102, Australia;[3]East China Normal Univ, State Key Lab Precis Spect, Shanghai 200062, Peoples R China;[4]Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China;[5]Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China;[6]Guangxi Univ Chinese Med, Guangxi Sci Res Ctr Tradit Chinese Med, Nanning 530200, Guangxi, Peoples R China;[7]Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang 110016, Liaoning, Peoples R China

年份：2018

卷号：29

期号：4

起止页码：1194

外文期刊名：BIOCONJUGATE CHEMISTRY

收录：;EI(收录号：20220411528110);WOS:【SCI-EXPANDED(收录号:WOS:000430641700040)】；

基金：The work is supported by the Fundamental Research Funds for the Central Universities (Nos. WY1514053, WY1516017), Shanghai Pujiang Program (16PJ1402500) and the National Natural Science Foundation of China (Nos. 21372080, 21572061, 11674101, 21236002, and 81502540).

语种：英文

摘要：Nitric oxide (NO) is a versatile endogenous molecule, involved in various physiological processes and implicated in the progression of many pathological conditions. Therefore, NO donors are valuable tools in NO related basic and applied applications. The traditional spontaneous NO donors are limited in scenarios where flux, localization, and dose of NO could be monitored. This has promoted the development of novel NO donors, whose NO release is not only under control, but also self-calibrated. Herein, we reported a phototriggered and photocalibrated NO donor (NOD565) with an N-nitroso group on a rhodamine dye. NOD565 is nonfluorescent and could release NO efficiently upon irradiation by green light. A bright rhodamine dye is generated as a side-product and its fluorescence can be used to monitor the NO release. The potentials of NOD565 in practical applications are showcased in in vitro studies, e.g., platelet aggregation inhibition and fungi growth suppression.