文献类型：期刊文献

英文题名：An enantioselective formal synthesis of (+)-(R)-α-lipoic acid by an L-proline-catalyzed aldol reaction

作者：Zhang, Shilei[1]; Chen, Xiaobei[2]; Zhang, Jiangang[2]; Wang, Wei[1,3]; Duan, Wenhu[1,2]

机构：[1] Department of Medicinal Chemistry, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; [2] Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China; [3] Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131-0001, United States

年份：2008

期号：3

起止页码：0383

外文期刊名：Synthesis

收录：EI(收录号：20080811114014)

语种：英文

外文关键词：Catalyst activity - Enantioselectivity - Synthesis (chemical)

摘要：An efficient, highly stereocontrolled formal synthesis of (+)-(R)-α-lipoic acid was achieved, which utilizes an L-proline-catalyzed highly enantio- and diastereoselective cross-aldol reaction as the key step. ? Georg Thieme Verlag Stuttgart.