文献类型：期刊文献

英文题名：Catalytic Asymmetric Construction of Quaternary -Amino Acid Containing Pyrrolidines through 1,3-Dipolar Cycloaddition of Azomethine Ylides to -Aminoacrylates

作者：Wang, Zheng[1,2];Luo, Shuai[1,2];Zhang, Shoude[1,2];Yang, Wu-Lin[1,2];Liu, Yang-Zi[1,2];Li, Honglin[1,2];Luo, Xiaoyan[1,2];Deng, Wei-Ping[1,2]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2013

卷号：19

期号：21

起止页码：6739

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20132116347664);WOS:【SCI-EXPANDED(收录号:WOS:000318923800025)，CCR-EXPANDED(收录号:WOS:000318923800025)】；

基金：The authors thank the Fundamental Research Funds for the Central Universities, the Shanghai Committee of Science and Technology (No. 11DZ2260600), the National Natural Science Foundation of China (No. 21172068), and the "Shu Guang" project of the Shanghai Education Development Foundation (No. 09SG28).

语种：英文

外文关键词：-amino acids; asymmetric catalysis; azomethine ylides; cycloaddition; silver

摘要：The first catalytic enantioselective 1,3-dipolar cycloaddition of azomethine ylides to -aminoacrylate catalyzed by a AgOAc/ferrocenyl oxazolinylphosphine (FOXAP) system was developed, which exhibits excellent exo- and enantioselectivity (9299%ee). This process provides efficient access to useful 4-aminopyrrolidine-2,4-dicarboxylic acid (APDC)-like compounds containing a unique quaternary -amino acid unit.