文献类型：专利

英文题名：Targeting prodrug prepared useful for inhibiting e.g. gastric cancer, arthritis, and viral infection, by preparing bioactive components and template molecular using peat, mixing, performing coupling reaction, and purifying product

作者：LIU Q;LV W;YANG J;ZHOU X

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY;[2]YUNNAN UNITED PHARM CO LTD

申请号：CN103690970-B

公开日：2015-03-18

语种：英文

收录：DERWENT

摘要：NOVELTY - Targeting prodrug prepared from peat, by producing bioactive components by mixing peat, penicillium, beta -lactamase, and actinomycetes with enzyme acetylcholine, hydrolyzing mixture, fermenting the mixture, preparation of template molecular by mixing peat and branches, poly phosphatase, xylanase, and/or yeast and amylase, performing enzymatic hydrolysis process, fermenting the mixture, mixing reaction solution B with A, performing coupling reaction, purifying product, and targeting prodrug. USE - The method is useful for targeting prodrug prepared from peat for inhibiting gastric cancer, lung cancer, arthritis, leukemia, and viral infection, preferably herpes viral infection (claimed). DETAILED DESCRIPTION - Targeting prodrug prepared from peat, involves (a) producing bioactive components by mixing peat, penicillium, beta -lactamase, and actinomycetes with enzyme acetylcholine under aerobic conditions, hydrolyzing mixture, and fermenting the mixture at 5-75 degrees C for 5-70 hours using Streptomyces griseus, S.auraofaciens, and Micromonospora echinospora, where bioactive component contain a reaction solution, (b) preparation of template molecular by mixing peat and branches, poly phosphatase, xylanase, and/or yeast and amylase under anaerobic conditions, performing enzymatic hydrolysis process, and fermenting the mixture at 5-50 degrees C for 5-50 hours, where the reaction solution containing imprinted molecule, and ratio of prepared bioactive components and template molecular is 1-5:2-10, and (c) mixing reaction solution B with A, performing coupling reaction, purifying product, and targeting prodrug.