文献类型：期刊文献

英文题名：Amphiphilic Deep Eutectic Solvent Based on Lidocaine and Lauric Acid: Formation of Microemulsion and Gel

作者：Wu, Jieyu[1];Yin, Tianxiang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2022

卷号：38

期号：3

起止页码：1170

外文期刊名：LANGMUIR

收录：;EI(收录号：20220611585763);WOS:【SCI-EXPANDED(收录号:WOS:000744970400001)】；

基金：This work was supported by the National Natural Science Foundation of China (Project 21773063).

语种：英文

外文关键词：Eutectics - Dynamic light scattering - High resolution transmission electron microscopy - Morphology - Saturated fatty acids - Solvents

摘要：Deep eutectic solvent (DES), as a new type of promising green solvent, showed great advantages of easy preparation and no need for purification after synthesis and displayed great potential applications in various fields. Herein, we have constructed a new type of therapeutic DES based on lidocaine and lauric acid. The DES displayed good surface activity in constructing a nonaqueous microemulsion with 1,2-propanediol (PG) and isopropyl myristate (IPM) being the polar phase and nonpolar phase, respectively. The obtained nonaqueous microemulsion displayed a structural transition from W/O type to O/W type via a bicontinuous structure with an increase of the PG content. The size, morphology, and microstructure of the microemulsion were explored using dynamic light scattering (DLS), transmission electron microscopy (TEM), and UV-vis absorption spectra measurements. Furthermore, this novel DES can act as a gelator to form a gel in a certain water content range. The rheological measurements suggested the presence of a strong colloidal force. Therefore, the results presented herein were expected to provide a new perspective in the applications of deep eutectic solvent as a surfactant.