文献类型：期刊文献

英文题名：Diffusion Behavior of Drug Molecules in Acrylic Pressure-Sensitive Adhesive

作者：Chen, Xuexue[2];Wang, Yaxin[2];Cheng, Zhipeng[2];Wei, Jie[3];Shi, Yifeng[1];Qian, Jun[2]

机构：[1]Hangzhou Rongfang Pressure Sensit New Mat Co Ltd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Adv Polymer Mat Shanghai, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Key Lab Ultrafine Mat Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：5

期号：16

起止页码：9408

外文期刊名：ACS OMEGA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000529926400038)】；

基金：This research was supported by the National Natural Science Foundation of China (grant numbers 81572194, 81771990).

语种：英文

摘要：Acrylic pressure-sensitive adhesive (PSA) is widely used in transdermal drug delivery systems, while the diffusion behavior of drug molecules in PSA is of great importance. In this paper, PSAs with different cross-link densities were prepared by adjusting the ratio of cross-linkers. The effects of cross-link density and temperature on the diffusion of drugs in PSA were investigated by Fourier transform infrared attenuated total reflectance and molecular dynamics simulation. The consistency between the experimental and simulation results demonstrated that molecular dynamics simulation could be used to predict the diffusion behavior of drugs in PSA. The results showed that free volume and the wriggling of polymer chains are positively related to the diffusion coefficient of drug molecules, while hydrogen bonds hinder drug diffusion.