文献类型：期刊文献

英文题名：Assimilation, distribution and toxicity of tetrabromobisphenol A to female Wistar rats through subchronic dermal exposure

作者：Yu, Yunjiang[1,2]; Xiang, Mingdeng[1,2]; Gao, Dandan[3]; Ye, Hao[3]; Wang, Qiong[4]; Zhang, Yanping[3]; Li, Liangzhong[1]; Li, Hui[5]

机构：[1] Center for Environmental Health Research, South China Institute of Environmental Sciences, MEP, Guangzhou, 510535, China; [2] State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China; [3] State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China; [4] Institute of Environmental Health and Related Product Safety, China CDC, Beijing, 100021, China; [5] State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, China

年份：2018

卷号：128

起止页码：171

外文期刊名：International Biodeterioration and Biodegradation

收录：EI(收录号：20174104241123)

语种：英文

外文关键词：Flame retardants - Biochemistry - Rats - Creatinine - Blood

摘要：Tetrabromobisphenol A (TBBPA) is one of the most widely used brominated flame retardants and is frequently detected in environmental and biological samples. While numerous studies have been conducted on the health effects and toxicokinetics upon oral exposure, few have explored other exposure routes. In the present study, TBBPA was administered to female Wistar rats for 90 days by repeated dermal exposure at 20, 60, 200 and 600 mg TBBPA/kg body weight, and subsequently the concentrations of TBBPA in serum, urine, and feces were determined. TBBPA concentration ranged between 38.26 and 115.9 μg/g lipid in serum, 0.62 and 1.02 ng/μM creatinine in urine, and 288.22 and 1815.66 μg/g in feces. Approximately 3.76–13.40% of the applied TBBPA were absorbed dermally and transported for distribution, but the amount of TBBPA detected in blood was relatively small. The majority of the TBBPA was excreted in feces after dermal exposure while small quantities of TBBPA were found in urine. No significant effects on animal growth or organ coefficients for the thymus, heart, lung, liver, kidneys, spleen, ovary, and brain were observed after subchronic dermal exposure to TBBPA. In addition, repeated dermal administration for 90 days did not induce visible skin pathologic lesions in the female Wistar rats. Our results show that the TBBPA via dermal exposure was mainly discharged through fecal route and residual concentration was low in blood, and the effects of TBBPA were not apparent in animals following subchronic dermal exposure. ? 2017