文献类型：期刊文献

中文题名：部分中和聚丙烯酸钠凝胶交联反应的动态流变分析

英文题名：Dynamic Rheological Analysis of Crosslinking Reaction of Partially Neutralised Sodium Polyacrylate Gels

作者：孟靖舒[1];王栋[1];郝大卫[2];李冰[1];杨锐[3,4]

机构：[1]华东理工大学机械与动力工程学院,上海200237;[2]上海希森生物医药材料科技有限公司,上海100044;[3]国家药品监督管理局药用辅料质量研究与评价重点实验室,北京100050;[4]中国食品药品检定研究院,北京100050

年份：2025

卷号：38

期号：6

起止页码：562

中文期刊名：功能高分子学报

外文期刊名：Journal of Functional Polymers

收录：;北大核心:【北大核心2023】；

语种：中文

中文关键词：部分中和聚丙烯酸钠;水凝胶;交联反应;流变;动力学;模型拟合

外文关键词：partially neutralised sodium polyacrylate;hydrogel;crosslinking reaction;rheology;dynamics;model fitting

摘要：采用6种不同的药用辅料——部分中和聚丙烯酸钠与甘羟铝交联制备了6种水凝胶,通过流变学手段测试了水凝胶交联60 d内的流变学特性参数,讨论了部分中和聚丙烯酸钠的分子量、中和度和pH对凝胶交联过程的影响。研究结果表明:水凝胶体系的交联反应分为3个阶段:快速反应阶段、慢速反应阶段和终止阶段。对部分中和聚丙烯酸钠与Al^(3+)的交联反应动力学曲线进行非线性最小二乘法拟合,其中慢速反应阶段采用Exp Assoc模型拟合的效果较好;快速反应阶段采用线性模型拟合的效果较好。对比6种部分中和聚丙烯酸钠对水凝胶性能的影响规律,部分中和聚丙烯酸钠的分子量越大,所制备的水凝胶弹性模量越高;部分中和聚丙烯酸钠的中和度越小,所制备的水凝胶成型时间越短;同等中和度,部分中和聚丙烯酸钠的pH越大,所制备的水凝胶反应速率越快。
Six different pharmaceutical excipients,partially neutralised sodium polyacrylates,were used to prepare hydrogels with aluminium glycolate,and the cross-linking reaction was investigated by rheological means.The dynamic rheological parameters of hydrogel cross-linking were studied over a period of 60 d and the effects of molecular weight,degree of neutrality and pH values of partially neutralised sodium polyacrylate on the cross-linking process of the gels were discussed in detail.The results showed that the cross-linking reaction of the hydrogel system could be divided into three distinct phases:a fast reaction phase,a slow reaction phase and a termination phase.Non-linear least squares fitting of the kinetic curves of the partially neutralised sodium polyacrylate/Al^(3+)cross-linking reaction showed that the slow reaction phase was better fitted by the Exp Assoc model,while the fast reaction phase was better fitted by the linear model.When comparing the effects of the six partially neutralised sodium polyacrylates on the hydrogel properties,the higher the molecular weight of the sodium polyacrylate,the higher the modulus of elasticity of the hydrogels.Conversely,a lower degree of neutrality resulted in shorter gel formation times.In addition,the reaction rate of hydrogels prepared from partially neutralised sodium polyacrylates increased with higher pH values at the same degree of neutrality.