文献类型：期刊文献

英文题名：Chiral squaramides catalyzed diastereo-and enantioselective Michael addition of α-substituted isocyanoacetates to N-aryl maleimides

作者：Zhao, Mei-Xin[1,2];Ji, Fei-Hu[1,2];Wei, Deng-Ke[1,2];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2013

卷号：69

期号：50

起止页码：10763

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000327692000009)，CCR-EXPANDED(收录号:WOS:000327692000009)】；

基金：We gratefully acknowledge National Natural Science Foundation of China (20772030, 21072056, 21272067) and the Fundamental Research Funds for the Central Universities for the financial support.

语种：英文

外文关键词：Isocyanoacetates; Maleimides; Michael addition; Squaramides; Organocatalysis

摘要：An efficient diastereo- and enantioselective Michael addition of a-substituted isocyanoacetates to N-aryl maleimides catalyzed by quinine or cyclohexane-1,2-diamine derived squaramide catalysts has been disclosed, affording the corresponding adducts in good yields (up to 99%), high diastereoselectivities (up to >20:1 dr) and good to excellent enantioselectivities (up to 94% ee) under mild conditions. (C) 2013 Elsevier Ltd. All rights reserved.