文献类型：期刊文献

英文题名：Synthesis and self-assembly of a hydrophilic, thermo-responsive poly(ethylene oxide) rnonomethyl ether-block-poly(acrylic acid)-block-poly (N-isopropylacrylamide) copolymer to form micelles for drug delivery

作者：He, Xiaohua[1];Wu, Xiaomeng[1];Gao, Chunyan[1];Wang, Kai[1];Lin, Shaoliang[2];Huang, Wei[1];Xie, Meiran[1];Yan, Deyue[1,3]

机构：[1]E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China;[2]E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Adv Polymer Mat Shanghai, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

年份：2011

卷号：71

期号：5

起止页码：544

外文期刊名：REACTIVE & FUNCTIONAL POLYMERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000290506800002)】；

基金：This work was financially supported by the Shanghai Natural Scientific Foundation of China (10ZR1409500 and 10ZR1407800). Support from Research Fund for the Doctoral Program of Higher Education of China (20100074120001) and Fundamental Research Fund for the Central Universities (WD0914031) is also appreciated.

语种：英文

外文关键词：Block copolymer; Micelles; Atom transfer radical polymerization; Thermo-responsive; Poly(N-isopropylacrylamide)

摘要：A hydrophilic, thermo-responsive triblock copolymer poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N-isopropylacrylamide) (MPEO-b-PAA-b-PNIPAM) was synthesized by sequential atom transfer radical polymerization and hydrolysis. These polymers were characterized in detail by H-1 NMR, FT-IR and gel permeation chromatography. In aqueous solution, MPEO-b-PAA-b-PNIPAM can self-assemble into core-shell-corona micelles above a LCST of the PNIPAM block. Condensation reactions easily cross-link the PAA shells, which enhances micellar stability. Doxorubicin (DOX), a model drug, was loaded into the core of the polymeric micelles and followed a pattern of thermo-sensitive drug release in vitro in cumulative release studies. (c) 2011 Elsevier Ltd. All rights reserved.