文献类型：期刊文献

英文题名：A Green Chemistry Method for the Regeneration of Carbonyl Compounds from Oximes by Using Cupric Chloride Dihydrate as a Recoverable Promoter for Hydrolysis

作者：Quan, Na[1];Shi, Xiao-Xin[1];Nie, Liang-Deng[1];Dong, Jing[1];Zhu, Rui-Heng[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Engn, Shanghai 200237, Peoples R China

年份：2011

期号：7

起止页码：1028

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000289411900036)，CCR-EXPANDED(收录号:WOS:000289411900036)】；

基金：We thank the National Natural Science Foundation of China (No. 20972048) and the Shanghai Educational Development Foundation (The Dawn Program: No. 03SG27) for the financial support of this work.

语种：英文

外文关键词：carbonyl compounds; oxime; hydrolysis; cupric chloride; green chemistry

摘要：A mild, efficient, general, and green method for the regeneration of carbonyl compounds from their corresponding oximes is described. Cupric salts promoted hydrolysis of oximes was studied, and the best reaction conditions for the hydrolysis have been found. Carbonyl compounds were obtained in 85-98% yields after the treatment of oximes with 2 molar equivalent of CuCl2 center dot 2H(2)O at reflux (around 75 degrees C) in a mixed solvent of acetonitrile and water (4:1). In addition, cupric salt was readily recovered in an almost quantitative yield via the complete precipitation of Cu(OH)(2)center dot 2H(2)O.