文献类型：期刊文献

英文题名：Synthesis and antimicrobial applications of α-peptoid polymers

作者：Xie, Jiayang[1];Hu, Weilong[2];Feng, Xi[2];Liu, Zixin[2];Zhou, Min[2,3];Liu, Runhui[1,2,3]

机构：[1]Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Shanghai 200237, Peoples R China

年份：2025

卷号：16

期号：28

起止页码：12679

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20252818740589);WOS:【SCI-EXPANDED(收录号:WOS:001522902600001)】；

基金：This research was supported by the National Natural Science Foundation of China (No. T2325010, 22305082, 52361165622, 22075078), Chinese Academy of Sciences Project for Young Scientists in Basic Research (Grant No. YSBR-111), the Science and Technology Innovation Action Plan Computational Biology Program (24JS2830400), the Fundamental Research Funds for the Central Universities (No. JKVD1251029, JKD01251701), Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission).

语种：英文

外文关键词：Antibiotics - Health risks - Microorganisms - Nitrogen - Proteolysis - Public health

摘要：The rapid evolution of drug-resistant pathogens and the lag in antibiotic development pose a severe threat to global public health. Host defense peptides (HDPs) have emerged as promising candidates due to their broad-spectrum antimicrobial activity and low resistance tendency. However, their practical application is hindered by poor proteolytic stability and high costs. Peptoids are ideal HDP mimics, as their characteristic side chain relocation from alpha-carbons to backbone nitrogen atoms confers superior proteolytic resistance. Nevertheless, their solid-phase synthesis remains inefficient and difficult to scale up. Recent advances in polymer chemistry enable the efficient synthesis of alpha-peptoid polymers, offering a promising platform for antimicrobial materials development. This perspective summarizes the progress in alpha-peptoid polymers research, focusing on monomer synthesis, polymerization reaction, and antimicrobial applications. We discuss their potential in the antimicrobial field and propose perspectives on current challenges and future directions, aiming to inspire further advances in the development of alpha-peptoid polymer-based antimicrobials with clinical application potential.