文献类型：期刊文献

英文题名：Organocatalytic Enantioselective aza-Friedel-Crafts Reactions of Pyrazolinone Ketimines with Hydroxyindoles and Electron-Rich Phenols

作者：Yang, Zhong-Tao[1,2];Yang, Wu-Lin[1,2];Chen, Long[1,2];Sun, Hao[1,2];Deng, Wei-Ping[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：360

期号：10

起止页码：2049

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000432704400020)，CCR-EXPANDED(收录号:WOS:000432704400020)】；

基金：This work is supported by the National Natural Science Foundation of China (No.21572053) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：aza-Friedel-Crafts; asymmetric organo-catalysis; pyrazolinone ketimines; hydroxyindoles; electron-rich phenols

摘要：A variety of enantioenriched indole derivatives substituted in the benzene ring were synthesised via an organocatalytic asymmetric aza-Friedel-Crafts reaction of pyrazolinone ketimines with hydroxyindoles. This reaction was also applicabled to electron-rich phenols, yielding the desired products in high yields (up to 99%) and excellent stereo-selectivities (91-99% ee). Moreover, this method presents its potential in the synthesis of structurally novel indole-pyrazolinone conjugate derivatives.