文献类型：期刊文献

英文题名：Enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated aldehydes

作者：Luo, Xiaoyan[1];Zhou, Zhiqiang[1];Li, Xin[1];Liang, Xinmiao[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Shanghai 200237, Peoples R China

年份：2011

卷号：1

期号：4

起止页码：698

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20121514932010);WOS:【SCI-EXPANDED(收录号:WOS:000295869400022)】；

基金：We are grateful for the financial support from National Natural Science Foundation of China (20902018), Shanghai Pujiang Program (08PJ1403300), the Fundamental Research Funds for the Central Universities and 111 Project (B07023).

语种：英文

外文关键词：Aldehydes - Addition reactions - Phosphorus compounds

摘要：The enantioselective organocatalytic phospha-Michael reaction of alpha,beta-unsaturated aldehydes with diaryl phosphine oxides is explored for the first time using (S)-2-(diphenyl(trimethylsilyloxy) methyl) pyrrolidine as a catalyst. It afforded 1,4-addition adducts in good to excellent yields with up to 99% ee.