文献类型：期刊文献

英文题名：3D skin models along with skin-on-a-chip systems: A critical review

作者：Sun, Wenxuan[1];Liu, Zijia[1];Xu, Jian[2];Cheng, Ya[2];Yin, Ruixue[1];Ma, Lei[3];Li, Honglin[3];Qian, Xuhong[3,4];Zhang, Hongbo[1]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China;[2]East China Normal Univ, Sch Phys & Elect Sci, Shanghai 200062, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[4]East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China

年份：2023

卷号：34

期号：5

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000948830300001)】；

语种：英文

外文关键词：3D skin model; Skin equivalent; Skin-on-a-chip; 3D bioprinting; Skin barrier

摘要：Skin is the largest organ in human body, and it plays an important role in regulating physiological mi-croenvironments and acts as a barrier to protect human body from harmful intrusions. The demand for fully functional skin models (also called skin equivalents, SE) in an in-vivo mimicking culturing microen-vironment has been increased dramatically due to the fast development in skin disease treatments and skin care products. Owing to the emerging of the concept and technology of organ-on-chips along with the three-dimensional (3D) bioprinting technology, 3D skin models and their applications have been fast evolving. In this paper, the advances in the development of 3D skin models along with skin-on-a-chip (SOC) are reviewed and commented. One of the findings with this paper is that the SOC together with the 3D bioprinting technology is promising to construct fully functional 3D skin models in the field of pharmaceutical and cosmetic industries. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.