文献类型：期刊文献

英文题名：A Br?nsted acid-promoted asymmetric intramolecular allylic amination of alcohols

作者：Zhou, Jianqiao[1]; Xie, Hexin[1]

机构：[1] State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China

年份：2018

卷号：16

期号：3

起止页码：380

外文期刊名：Organic and Biomolecular Chemistry

收录：EI(收录号：20180404679125)

语种：英文

摘要：Reported herein is a chiral Br?nsted acid-catalyzed asymmetric intramolecular allylic amination reaction, allowing facile access to a range of biologically interesting chiral 2-substituted hydroquinolines in up to 90% yield and with up to 93% ee. Furthermore, a significant effect of an N-protecting group was observed in this asymmetric process. ? 2018 The Royal Society of Chemistry.