文献类型：期刊文献

英文题名：Microporous Coatings of PEKK/SN Composites Integration with PEKK Exhibiting Antibacterial and Osteogenic Activity, and Promotion of Osseointegration for Bone Substitutes

作者：Wu, Han[1];Yang, Lili[2];Qian, Jun[1];Wang, Deqing[1];Pan, Yongkang[1];Wang, Xuehong[1];Saha, Nabanita[3];Tang, Tingting[4];Zhao, Jun[5];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Dept Orthopaed Surg, Changzheng Hosp, Shanghai 200003, Peoples R China;[3]Tomas Bata Univ, Ctr Polymer Syst, Univ Inst, Tr T Bati 5678, Zlin 76001, Zlin, Czech Republic;[4]Shanghai Jiao Tong Univ, Shanghai Key Lab Orthopaed Implants, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Shanghai 200011, Peoples R China;[5]Shanghai Jiao Tong Univ, Shanghai Key Lab Stomatol, Shanghai Peoples Hosp 9, Dept Orthodont, Shanghai 200011, Peoples R China

年份：2019

卷号：5

期号：3

起止页码：1290

外文期刊名：ACS BIOMATERIALS SCIENCE & ENGINEERING

收录：;EI(收录号：20191006606299);WOS:【SCI-EXPANDED(收录号:WOS:000461270200013)】；

基金：The grants were from the National Natural Science Foundation of China (81572194 and 81771990), Key Medical Program of Science and Technology Development of Shanghai (17441900600 and 17441902000) as well as by the Ministry of Education, Youth and Sports of the Czech Republic -Program NPU I (LO1504).

语种：英文

外文关键词：poly(etherketoneketone); silicon nitride; microporous coating; antibacterial activity; osteogenic activity

摘要：To improve the antibacterial and osteogenic activities of poly(etherketoneketone) (PEKK), concentrated sulfuric acid (H2SO4) suspension with silicon nitride (SN) microparticle was utilized to modify PEKK surface. Through sulfonation reaction, microporous coatings of PEKK/SN composites were created on PEKK surface, which were integrated with PEKK substrate. The results showed that the content of SN in the microporous coatings increased with the increase of SN content in H2SO4 suspension (PKS without SN, PKSCS and PKSC10 with 5 and 10 wt % SN content in H2SO4) and that the surface roughness and hydrophilicity of microporous coatings on PEKK were significantly improved with the SN content increasing. In addition, the microporous coating of PKSC10 with high SN content exhibited excellent antibacterial activity due to the synergistic action of the presence of amino (-NH2) and sulfonic acid (-SO3H) groups as well as the improvement of protein absorption. Moreover, the microporous coating of PKSC10 obviously stimulated adhesion, proliferation, and osteogenic differentiation of rat bone mesenchymal stem cells. Furthermore, histological and push-out load evaluation indicated that the microporous coating of PKSC10 significantly promoted osteogenesis and osseointegration in vivo. The results suggested that the microporous coating of PKSC10 with high SN content display good biocompatibility, antibacterial and osteogenic activities, and osseointegration ability, which would have great potential for bone substitutes.