文献类型：期刊文献

英文题名：Biomimetic Strain-Stiffening Self-Assembled Hydrogels

作者：Wang, Yiming[1];Xu, Zhi[1];Lovrak, Matija[2];le Sage, Vincent A. A.[2];Zhang, Kai[2];Guo, Xuhong[1];Eelkema, Rienk[2];Mendes, Eduardo[2];van Esch, Jan H.[2]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Sch Chem Engn, Meilong Rd 130, Shanghai 200237, Peoples R China;[2]Delft Univ Technol, Dept Chem Engn, Maasweg 9, NL-2629 HZ Delft, Netherlands

年份：2020

卷号：59

期号：12

起止页码：4830

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20200508111370);WOS:【SCI-EXPANDED(收录号:WOS:000509592600001)】；

基金：We thank Dr. J. M. Poolman and Dr. C. Maity for providing H, A, A-, and A-FL. We would like to acknowledge NSFC Grant (21908061), Fundamental Research Funds for the Central Universities (50621011901008) and China Scholarship Council (CSC) for financial support.

语种：英文

外文关键词：gels; low-molecular-weight gelators; self-assembly; strain-stiffening; supramolecular chemistry

摘要：Supramolecular structures with strain-stiffening properties are ubiquitous in nature but remain rare in the lab. Herein, we report on strain-stiffening supramolecular hydrogels that are entirely produced through the self-assembly of synthetic molecular gelators. The involved gelators self-assemble into semi-flexible fibers, which thereby crosslink into hydrogels. Interestingly, these hydrogels are capable of stiffening in response to applied stress, resembling biological intermediate filaments system. Furthermore, strain-stiffening hydrogel networks embedded with liposomes are constructed through orthogonal self-assembly of gelators and phospholipids, mimicking biological tissues in both architecture and mechanical properties. This work furthers the development of biomimetic soft materials with mechanical responsiveness and presents potentially enticing applications in diverse fields, such as tissue engineering, artificial life, and strain sensors.