文献类型：期刊文献

中文题名：Synthesis,nematicidal evaluation,and SAR study of benzofuran derivatives containing 2-carbonyl thiophene

作者：Xiaofeng Cao[1];Die Qiu[1];Ruifeng Zhang[1];Zhong Li[1];Xiaoyong Xu[1]

机构：[1]Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China

年份：2023

卷号：34

期号：5

起止页码：456

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：financial supported by the National Natural Science Foundation of China(No.21672061);National Key Research Program of China(No.2018YFD0200105);supported by Innovation Program of Shanghai Municipal Education Commission(No.201701070002E00037);the Fundamental Research Funds for the Central Universities。

语种：英文

中文关键词：Benzofuran;Nematicide;M.incognita;C.elegans;Structure-activity relationship

摘要：Plant-parasitic nematodes are major threat for crop protection.The lack of nematicides with new mode of action and increasing resistance raises the need for novel nematicides.In order to seek new nematicidal lead,originating from the structure of chalcone,a series of fused ring compounds was obtained by ring closure design strategy.These compounds were modified further.The nematicidal activity against M.incognita of synthesized compounds was evaluated.The bioassay showed that compound 3 and some of its derivatives such as compounds 18,19,21,22,23,24 and 26 exhibited excellent nematicidal activity.Among them,compound 23 exhibited significant bioactivity.The LC50/72 hvalue reached 3.20 mg/L in vitro and the inhibition rate was 100.00%at 40 mg/L in the matrix.The structure-activity relationship of synthesized compounds was discussed in details.The influence of compound 23 on egg hatching,motility,and feeding behavior of C.elegans was also evaluated.