文献类型：期刊文献

英文题名：A hyaluronic acid/graphene oxide hydrogel for enhanced ex vivo expansion of cord blood-derived CD34+ cells

作者：Guo, Wenzhen[1];Pan, Xiuwei[1];Zhang, Yuanhao[1];Cai, Haibo[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Coll Chem & Mol Engn, Shanghai Key Lab Chem & Funct Mat, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：205

起止页码：253

外文期刊名：MATERIALS LETTERS

收录：;EI(收录号：20172603846436);WOS:【SCI-EXPANDED(收录号:WOS:000405458800063)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 21574039 and 51173044), and the Science and Technology Commission of Shanghai Municipality (No. 15JC1401402).

语种：英文

外文关键词：Biomaterials; Polymers; Graphene oxide; Stem cell; Ex vivo expansion

摘要：HA/GO hydrogels were prepared by methacrylated GO (MeGO) and methacrylated HA (MeHA) via an in-situ free radical polymerization, and then a series of HA/GO hydrogels with highly porous structure were obtained. All hydrogels exhibited excellent water absorption ability. Additionally, the elastic moduli of hydrogels were clearly enhanced by GO. CD34(+) cells cultured on HA/GO-0.05 hydrogel showed higher expansion of CD34(+) cells and CD34(+) CD38(-) cells compared to the other three hydrogels. Therefore, HA/GO-0.05 hydrogels have a potential for clinical-applied ex vivo expansion of hematopoietic stem cells. (C) 2017 Elsevier B.V. All rights reserved.