文献类型：期刊文献

英文题名：Nanopipettes for Chemical Analysis in Life Sciences

作者：Zheng, Shiyu[1];Wu, Mansha[1];Wang, Xiaoyuan[1];Xu, Shuyue[1];Qian, Ruocan[1]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat,Joint Int Lab, Shanghai 200237, Peoples R China

年份：2025

卷号：26

期号：7

外文期刊名：CHEMBIOCHEM

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001442469100001)】；

基金：This research was supported by National Natural Science Foundation of China (21977031), Shanghai Science and Technology Committee (22ZR1416800, 23ZR1416100), and the Fundamental Research Funds for the Central Universities (222201717003). Finally, the authors thank the Research Center of Analysis and Test of East China University of Science and Technology for the help on characterization.

语种：英文

外文关键词：nanopipettes; fabrication; modification methods; electrochemistry; sensors

摘要：Nanopipette-based assays have gained widespread applications in electrochemical and analytical technologies, achieving significant advancements over the past decade in DNA sequencing, biosensing, targeted delivery, and bioimaging. The ultrasmall tip size of nanopipettes bridges the gap between the macro- and nano worlds, which can be attributed to the capability of nanopipettes to transport ultrasmall volumes of liquids, ions, and solutes. In this review, we discuss the fabrication, characterization, and modification of nanopipettes to provide an overview of the recent developments of nanopipette-based sensors and strategies. We also introduce the recent studies developed by our group and other groups using nanopipettes for chemical analysis of life science. Finally, we discuss the future development of nanopipette-based strategies and their exciting potential for studying bioscience and biomedical engineering.