文献类型：期刊文献

英文题名：Fabrication of biocompatible nanohybrid shish-kebab-structured carbon nanotubes with a mussel-inspired layer

作者：Wu, Tong[1,2,3];Sha, Jin[1,3];Peng, Yiyan[2];Chen, Xin[1,2,3];Xie, Linsheng[1,3];Ma, Yulu[1,3];Turng, Lih-Sheng[2]

机构：[1]East China Univ Sci & Technol, Minist Educ, Engn Ctr Efficient Green Proc Equipment & Energy, Shanghai 200237, Peoples R China;[2]Univ Wisconsin, Wisconsin Inst Discovery, Madison, WI 53715 USA;[3]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China

年份：2016

卷号：6

期号：103

起止页码：101660

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20164502981177);WOS:【SCI-EXPANDED(收录号:WOS:000387427700116)】；

基金：The authors sincerely acknowledge the support of Fundamental Research Funds for the Central Universities [22A201514030], China Postdoctoral Science Foundation [2015M571504], National Natural Science Foundation of China [51503065, 51273065], China Scholarship Council, and the Wisconsin Institute for Discovery in University of Wisconsin-Madison.

语种：英文

外文关键词：Cell engineering - Biocompatibility - Cells - Scaffolds (biology) - Cell adhesion - Fabrication - Cell culture - Yarn

摘要：In this study, a carbon nanotubes (CNTs)/polyethylene (PE) nanohybrid shish-kebab (NHSK) structure was fabricated and subsequently coated with a polydopamine (PDA) layer. This work aims to introduce the nano-sized topography and the high biocompatibility of PDA into CNTs to enhance cell affinity. The NHSK architecture was fabricated with CNTs and PE via a solution crystallization technique. The nanotopology of the shish-kebab structure can be tailored by adjusting the PE concentration and crystallization time. Moreover, dopamine self-polymerization was subsequently utilized to coat a thin and immobilized layer of bioactive PDA around the NHSK, which showed enhanced hydrophilicity compared with uncoated NHSK scaffolds. Cell assays with fibroblasts demonstrated that the nanotopography of the kebab crystals and their dimensions enhanced cell attachment and spreading while the PDA functionalization on the NHSK scaffolds further facilitated cell adhesion and viability, indicating that this study has potential applications in tissue engineering.