文献类型：期刊文献

英文题名：Advances in sophorolipid-producing strain performance improvement and fermentation optimization technology

作者：Li, Ya[1];Chen, Yang[1];Tian, Xiwei[1];Chu, Ju[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, POB 329,130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2020

卷号：104

期号：24

起止页码：10325

外文期刊名：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

收录：;EI(收录号：20204409410989);WOS:【SCI-EXPANDED(收录号:WOS:000582085600002)】；

基金：This work was financially supported by the National Key Research Development Program of China (No. 2019YFA0904800) and the Fundamental Research Funds for the Central Universities, China (WF1814032, 22221818014).

语种：英文

外文关键词：Sophorolipids; Strain performance; Fermentation process optimization; Biosurfactant

摘要：Sophorolipids (SLs), currently one of the most promising biosurfactants, are secondary metabolites produced by many non-pathogenic yeasts, among which Candida bombicola ATCC 22214 is the main sophorolipid-producing strain. SLs have gained much attention since they exhibit anti-tumor, anti-bacterial, anti-inflammatory, and other beneficial biological activities. In addition, as biosurfactants, SLs have a low toxicity level and are easily degradable without polluting the environment. However, the production cost of SLs remains high, which hinders the industrialization process of SL production. This paper describes SL structure and the metabolic pathway of SL synthesis firstly. Furthermore, we analyze factors that contribute to the higher production cost of SLs and summarize current research status on the advancement of SL production based on two aspects: (1) the improvement of strain performance and (2) the optimization of fermentation process. Further prospects of lowering the cost of SL production are also discussed in order to achieve larger-scale SL production with a high yield at a low cost.