文献类型：期刊文献

英文题名：Synthesis, Characterization and Near-Infrared Driven the Generation of Singlet Oxygen and Photothermal Property of a Meso-Protonated Iridium(Iii) Α-Octabutoxyphthalocyanine

作者：Chen, Xu[2]; Deng, Xin'Ao[1]; Qiu, Zhiheng[1]; Wang, Jie[1]; Yang, Hong[1]

机构：[1] College of Chemistry and Material Science, Shanghai Normal University, Shanghai, 200234, China; [2] Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Meilong Road 130, Shanghai, 200237, China

年份：2024

外文期刊名：SSRN

收录：EI(收录号：20240222772)

语种：英文

外文关键词：Chlorine compounds - Conversion efficiency - Fluorine compounds - Infrared devices - Iridium compounds - Irradiation - Oxygen - Photodynamic therapy - Protonation

摘要：A stable iridium(III) meso-protonated α-octabutoxy phthalocyanine, denoted as [IrPcH(OBu)8Cl2], has been successfully synthesized. The primary absorption peak was observed at ～ 819 nm accompanied by two shoulder peaks around 755 and 708 nm in CH2Cl2 and THF solution, while the primary absorption peak was located at ～708 nm in DMF and DMSO solution with the shoulder peak about 630 nm, respectively. Considering a proton on the meso-N position in the iridium(III) α-octabutoxy phthalocyanine complex, the interaction between [IrPcH(OBu)8Cl2] and fluoride ions was investigated. Due to the strong near-infrared absorption property of a meso-protonated metal phthalocyanine and the heavy atom effect of an iridium(III), [IrPcH(OBu)8Cl2] exhibits the enhanced generation of singlet oxygen and the photothemal property with the photothermal conversion efficiency of ～25% driven by 808 nm laser irradiation. This performance opens an avenue for the potential application of [IrPcH(OBu)8Cl2] in photodynamic/photothermal synergic therapy, particularly in conjunction with NIR laser irradiation. ? 2024, The Authors. All rights reserved.