文献类型：期刊文献

英文题名：Mussel-inspired dopamine-CuII coated polyetheretherketone surface with direct and immunomodulatory effect to facilitate osteogenesis, angiogenesis, and antibacterial ability

作者：Lyu, Zhuocheng[1];Zhao, Yaochao[1];Huo, Shicheng[2];Wang, Fan[3];Meng, Xiangchao[1];Yuan, Zhiguo[1];Long, Teng[1];Wang, You[1]

机构：[1]Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Bone & Joint Surg,Dept Orthoped, Shanghai 200127, Peoples R China;[2]Navy Med Univ, Changzheng Hosp, Dept Orthoped Surg, Spine Ctr, Shanghai 200003, Peoples R China;[3]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2022

卷号：222

外文期刊名：MATERIALS & DESIGN

收录：;EI(收录号：20223512630951);WOS:【SCI-EXPANDED(收录号:WOS:000891954200007)】；

基金：This study was supported by the National Key R&D Program of China (Grant No. 2016YFC1101802) and the Natural Science Foundation of China (Grant No. 81501855).

语种：英文

外文关键词：Polyetheretherketone; Copper; Immunomodulation; Antibacterial; Osseointegration

摘要：Implant-associated infection (IAI) and insufficient implant osseointegration are two primary concerns of implant failure. Polyetheretherketone (PEEK), though widely used in orthopedic implants, has been limited in clinical applications by its poor osteogenic activity, inferior antibacterial ability, and improper immunological reactions. In this study, copper (Cu), a multi-functional bioactive ion, is incorporated into the polydopamine (PDA) coating on PEEK surfaces using a metal-catecholamine assembling strategy. This DA-Cu-II coating induces a spatial distribution of Cu, exerting biological functions simultaneously through passive contact and active release of Cu. DA-Cu-II coated PEEK surfaces exhibit not only superior abilities of osteogenesis, angiogenesis, and antibiosis but also possess immunomodulatory effects to enhance macrophages-mediated osteogenesis and antibacterial activity. Moreover, the DA-Cu-II coated PEEK induces a mild and necessary inflammatory response, exhibiting excellent antibacterial yability and superior osseointegration. Our findings suggest that DA-Cu-II coated PEEK has excellent potential for orthopedic implants and provides new insight into novel modification strategies of PEEK materials. (C) 2022 The Authors. Published by Elsevier Ltd.