文献类型：专著

英文题名：Advances and Practices of Bioprocess Scale-up

作者：Xia, Jianye[1];Wang, Guan[1];Lin, Jihan[1];Wang, Yonghong[1];Chu, Ju[1];Zhuang, Yingping[1];Zhang, Siliang[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

出版社：SPRINGER-VERLAG BERLIN

出版日期：20160101

出版地：HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY

页数：15

纸书定价：0

isbn号：978-3-662-48347-3; 978-3-662-48346-6

语种：英文

外文关键词：Bioprocess engineering; Scale-up; Bioprocess monitoring; Fluid dynamics; Microbial kinetics; Mathematical model

摘要：This chapter addresses the update progress in bioprocess engineering. In addition to an overview of the theory of multi-scale analysis for fermentation process, examples of scale-up practice combining microbial physiological parameters with bioreactor fluid dynamics are also described. Furthermore, the methodology for process optimization and bioreactor scale-up by integrating fluid dynamics with biokinetics is highlighted. In addition to a short review of the heterogeneous environment in large-scale bioreactor and its effect, a scale-down strategy for investigating this issue is addressed. Mathematical models and simulation methodology for integrating flow field in the reactor and microbial kinetics response are described. Finally, a comprehensive discussion on the advantages and challenges of the model-driven scale-up method is given at the end of this chapter.