文献类型：期刊文献

中文题名：A New Synthetic Method of （Z）-4-Aryl-but-2-en-l-ols via Suzuki-Miyaura Cross-Coupling Reaction of 4-Substituted 1,2-Oxaborol-2（5H）-ols with Benzyl Bromides

英文题名：A New Synthetic Method of （Z）-4-Aryl-but-2-en-l-ols via Suzuki-Miyaura Cross-Coupling Reaction of 4-Substituted 1,2-Oxaborol-2（5H）-ols with Benzyl Bromides

作者：Yu Tao[1];Wu Xinyan[1];Yang Jun[2]

机构：[1]Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China;[2]Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Road, Shanghai 200032, China

年份：2012

卷号：30

期号：12

起止页码：2798

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2011_2012】；

基金：support from National Natural Science Foundation of China （Nos. 20802088, 91017006, 90917017） and the Fundamental Research Funds for the Central Universities.

语种：英文

中文关键词：Suzuki-Miyaura cross-coupling reaction; palladium-catalyzed; （Z）-but-2-en-l-ols; benzyl bromides

外文关键词：Suzuki-Miyaura cross-coupling reaction; palladium-catalyzed; （Z）-but-2-en-l-ols; benzyl bromides

摘要：Z and E configuration 4-aryl-but-2-en-1-ols were isolated from several terrestrial plants, and （Z）-4-aryl-but-2- en-l-ols were found to have choleretic activity. Strategies have been reported to synthesize （E）-4-aryl-but-2-en-l- ols with high selectivity. However, there is no method to obtain （Z）-4-aryl-but-2-en-1-ols with high selectivity now. We developed a Suzuki-Miyaura cross-coupling reaction of 1,2-oxaborol-2（5H）-ols with benzyl bromides to synthesize （Z）-4-aryl-but-2-en-1-ols, the products were obtained in up to 94% isolated yield.
Z and E configuration 4-aryl-but-2-en-1-ols were isolated from several terrestrial plants, and （Z）-4-aryl-but-2- en-l-ols were found to have choleretic activity. Strategies have been reported to synthesize （E）-4-aryl-but-2-en-l- ols with high selectivity. However, there is no method to obtain （Z）-4-aryl-but-2-en-1-ols with high selectivity now. We developed a Suzuki-Miyaura cross-coupling reaction of 1,2-oxaborol-2（5H）-ols with benzyl bromides to synthesize （Z）-4-aryl-but-2-en-1-ols, the products were obtained in up to 94% isolated yield.