文献类型：期刊文献

英文题名：Development of a BODIPY-based ratiometric fluorescent probe for hypochlorous acid and its application in living cells

作者：Wang, Xuzhe[1,2];Zhou, Li[3];Qiang, Fei[1,2];Wang, Feiyi[1,2];Wang, Rui[3];Zhao, Chunchang[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2016

卷号：911

起止页码：114

外文期刊名：ANALYTICA CHIMICA ACTA

收录：;EI(收录号：20160601895461);WOS:【SCI-EXPANDED(收录号:WOS:000370186000013)】；

基金：We gratefully acknowledge the financial support by the National Science Foundation of China (grant no.: 21172071, 21190033, 21372083).

语种：英文

外文关键词：Ratiometric detection; Fluorescent probe; Hypochlorous acid; High selectivity; pH-independency

摘要：A BODIPY-based ratiometric fluorescent probe for HOCl has been designed based on the transduction of thioether to sulfoxide function. This probe features a marked absorption and emission blue-shift upon the HOCl-promoted rapid transduction, enabling the highly selective and ratiometric detection. In addition, the probe works excellently within a wide pH range of 4-10, addressing the existing pH dependency issue. Living cells studies demonstrate that the probe is cell membrane permeable and can be employed successfully to image endogenous HOCl generation in macrophage cells. (C) 2016 Elsevier B.V. All rights reserved.