文献类型：期刊文献

英文题名：Pd-Catalyzed Csp2-H Functionalization of Heteroarenes via Isocyanide Insertion: Concise Synthesis of Di-(Hetero)Aryl Ketones and Di-(Hetero)Aryl Alkylamines

作者：Sharma, Upendra K.[1];Sharma, Nandini[1];Xu, Jun[1,2];Song, Gonghua[2];van der Eycken, Erik V.[1]

机构：[1]Univ Louvain, Dept Chem, LOMAC, KU Leuven, B-3001 Louvain, Belgium;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2015

卷号：21

期号：13

起止页码：4908

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20151100644162);WOS:【SCI-EXPANDED(收录号:WOS:000352140000004)，CCR-EXPANDED(收录号:WOS:000352140000004)】；

基金：Support was provided by the Research Fund of the University of Leuven (KU Leuven) and the FWO (Fund for Scientific Research Flanders (Belgium). U.K.S. and N.S. are thankful to KU Leuven for providing post-doctoral fellowship. J.X. is thankful to the CSC, China for providing a doctoral exchange scholarship.

语种：英文

外文关键词：azoles; C-H activation; heteroarenes; isocyanide insertion; palladium

摘要：We report herein an efficient Pd-catalyzed direct C-H bond functionalization of heteroarenes via an isocyanide insertion strategy for the synthesis of di-(hetero) aryl ketones and di-(hetero) aryl alkylamines. The methodology involves a three component reaction between an azole, a haloarene and an isocyanide resulting in the formation of an imine, which in turn is either hydrolyzed or reduced to get the desired product.