文献类型：期刊文献

英文题名：Uniform Rattle-type Hollow Magnetic Mesoporous Spheres as Drug Delivery Carriers and their Sustained-Release Property

作者：Zhao, Wenru[1];Chen, Hangrong[2];Li, Yongsheng[1];Li, Liang[1];Lang, Meidong[1];Shi, Jianlin[1,2]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2008

卷号：18

期号：18

起止页码：2780

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20084311650478);WOS:【SCI-EXPANDED(收录号:WOS:000259933000016)】；

基金：The authors gratefully acknowledge the support of the Shanghai NanoScience Program (Grant No. 0652 nm014), the National Natural Science Foundation of China (Grant No. 20571081), the National Hi-Tech Project of China (Grant No. 2007AA03Z317), the Chinese Academy of Sciences (Grant No. KJCX2.YW.M02), and the China Postdoctoral Science Foundation (Grant No. 20070410697).

语种：英文

外文关键词：Fick&apos - s laws - Mesoporous materials - Drug products - Hematite - Silica - Sol-gels - Magnetite - Targeted drug delivery

摘要：A novel kind of rattle-type hollow magnetic mesoporous sphere (HMMS) with Fe3O4 particles encapsulated in the cores of mesoporous silica microspheres has been successfully fabricated by sol-gel reactions on hematite particles followed by cavity generation with hydrothermal treatment and H, reduction. Such a structure has the merits of both enhanced drug-loading capacity and a significant magnetization strength. The prepared HMMSs realize a relatively high storage capacity up to 302 mg g(-1) when ibuprofen is used as a model drug, and the IBU-HMMS system has a sustained-re lease property, which follows a Fick's law.