文献类型：期刊文献

英文题名：Regulation of Bone Remodeling by Metal-Phenolic Networks for the Treatment of Systemic Osteoporosis

作者：Chen, Xi[1];Wu, Weihui[1];Zhu, Wei[2];Zhou, Jiajing[3];Chen, Jingqu[4];Lin, Zhixing[4];Zhang, Sixian[1];Caruso, Frank[4];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ,Frontiers Sci Ct, Shanghai 200237, Peoples R China;[2]South China Univ Technol, Sch Biol & Biol Engn, MOE Int Joint Res Lab Synthet Biol & Med, Guangzhou 510006, Peoples R China;[3]Sichuan Univ, Coll Biomass Sci & Engn, Key Lab Leather Chem & Engn, Natl Engn Lab Clean Technol Leather Manufacture,Mi, Chengdu 610065, Peoples R China;[4]Univ Melbourne, Dept Chem Engn, Parkville, Vic 3010, Australia

年份：2025

卷号：17

期号：4

起止页码：5995

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20250417748799);WOS:【SCI-EXPANDED(收录号:WOS:001399629600001)】；

基金：This work was supported by grants from the National Natural Science Foundation of China (Grants T2288102, 32371464 and 32101151), and the National High-Tech Research and Development Program (Grant 2022YFC2403200).

语种：英文

外文关键词：MPN nanoparticles; osteoporosis; bone targeting; osteoblastic bone formation; osteoclastic bone resorption

摘要：Osteoporosis is a systemic metabolic disease that impairs bone remodeling by favoring osteoclastic resorption over osteoblastic formation. Nanotechnology-based therapeutic strategies focus on the delivery of drug molecules to either decrease bone resorption or increase bone formation rather than regulating the entire bone remodeling process, and osteoporosis interventions suffer from this limitation. Here, we present a multifunctional nanoparticle based on metal-phenolic networks (MPNs) for the treatment of systemic osteoporosis by regulating both osteoclasts and osteoblasts. In the osteoporotic microenvironment, the MPN nanoparticles degrade and trigger the release of bioactive metals (strontium ions, SrII) to promote osteogenesis and functionalized phenols (epigallocatechin gallate, EGCG) to suppress osteoclastogenesis. Injecting these nanoparticles into the tail vein of an ovariectomized mouse model, trabecular bone loss has been significantly prevented in the femoral head and vertebrae, along with increased trabecular bone volume and decreased trabecular bone separation. Overall, this work represents a versatile approach to explore MPN nanomaterials for the treatment of systemic osteoporosis and related orthopedic diseases.