文献类型：期刊文献

英文题名：Synthesis, structure and DNA cleavage of mononuclear Fe(III) complexes with 1,2,4-triazole-base ligand

作者：Liu, Hui[1,2];Kou, Ying-ying[1];Feng, Li[3];Li, Dong-dong[1];Gao, Chun-Yan[1];Tian, Jin-lei[1];Zhang, Jing-yan[2];Yan, Shi-ping[1]

机构：[1]Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China

年份：2010

卷号：24

期号：9

起止页码：636

外文期刊名：APPLIED ORGANOMETALLIC CHEMISTRY

收录：;EI(收录号：20103613221820);WOS:【SCI-EXPANDED(收录号:WOS:000281472200004)】；

基金：This work was supported by the National Natural Science Foundation of China (no. 20771063).

语种：英文

外文关键词：iron (III) complex; 1,2,4-triazole; crystal structure; DNA binding; DNA cleavage

摘要：Two new mononuclear iron(III) complexes, [Fe(HL)(2)](ClO4) center dot (H2O)(1.75) center dot CH3CN (1) and [Fe(HL)Cl-2] center dot DMF (2) (H2L = 3-(2-phenol)5-(pyridin-2-yl)-1,2,4-triazole) have been synthesized and characterized by X-ray single-crystal structure analysis. The single crystal X-ray crystallographic studies reveal that the central iron atom has a distorted octahedral environment for 1 and a distorted square pyramidal geometry for 2. The DNA cleavage activity of the iron(III) complexes was measured, indicating that the six-coordinated iron(III) (complex 1) was cleavage inactive and only five-coordinated complex 2 effectively promoted the cleavage of plasmid DNA in the presence and/or absence of activating agents (peroxide oxygen) at physiological pH and temperature. The mechanism of plasmid DNA cleavage was also studied by adding standard radical scavengers. Copyright (C) 2010 John Wiley & Sons, Ltd.