文献类型：期刊文献

英文题名：Facile Synthesis of Magnetite/Perfluorocarbon Co-Loaded Organic/Inorganic Hybrid Vesicles for Dual-Modality Ultrasound/Magnetic Resonance Imaging and Imaging-Guided High-Intensity Focused Ultrasound Ablation

作者：Niu, Dechao[1];Wang, Xia[2];Li, Yongsheng[1];Zheng, Yuanyi[3];Li, Faqi[4];Chen, Hangrong[2];Gu, Jinlou[1];Zhao, Wenru[1];Shi, Jianlin[1,2]

机构：[1]E China Univ Sci & Technol, Lab Low Dimens Mat Chem, Key Lab Ultrafine Mat, Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China;[3]Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China;[4]Chongqing Med Univ, Chongqing Key Lab Ultrasound Med & Engn, Coll Biomed Engn, Chongqing 400016, Peoples R China

年份：2013

卷号：25

期号：19

起止页码：2686

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20132116351403);WOS:【SCI-EXPANDED(收录号:WOS:000318808300006)】；

基金：This work was financially supported by the National Basic Research Program of China (973 Program, 2012CB933602), the National Natural Science Foundation of China (grant nos. 51172070, 51132009, and 51202068), the Program for New Century Excellent Talents in University (NCET-10-0379), the Scientific Innovation Project of Shanghai Municipal Education Commission (grant no. 11ZZ53), and the Fundamental Research Funds for the Central Universities (grant nos. WD1114002 and WD1214010). The authors are grateful to Dr. Xiaohang Liu and Prof. Liangping Zhou from Shanghai Cancer hospital for MRI.

语种：英文

外文关键词：vesicles; nanoparticles; magnetic; perfluorocarbons; magnetic resonance imaging; ultrasound; HIFU therapy

摘要：Multifunctional organic/inorganic hybrid nanovesicles, fabricated by a facile self-assembly/sol-gel approach, display a unique morphology (figure) and satisfactory stability under physiological conditions. By co-encapsulation of superparamagnetic magnetite nanoparticles and a liquid perfluorocarbon, the nanovesicles can be used not only as a dual-modality ultrasound/magnetic resonance contrast agent for accurate cancer diagnosis and monitoring, but also as a therapeutic enhancement agent for effective high-intensity focused ultrasound (HIFU) ablation. Copyright ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.