文献类型：期刊文献

英文题名：Fabrication of poly(D, L-lactide-co-ε-caprolactone) with elastic-memory function and controlled biodegradability

作者：Wei, Lingyu[1,2];Chen, Qi[1,2];Zhou, Dong[1,2];Gu, Lamei[1,2];Zhang, Shuyan[1,2];Zhang, Shihao[1,2];Rafique, Muhammad[3,4];Xiao, Lan[5];Li, Yulin[1,2,6]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai, Peoples R China;[4]Shanghai Jiao Tong Univ, Med X Res Inst, Shanghai, Peoples R China;[5]Griffith Univ, Sch Med & Dent, Gold Coast, Australia;[6]Shanghai Univ, Wenzhou Inst, Wenzhou, Peoples R China

年份：2026

卷号：75

期号：2

起止页码：183

外文期刊名：INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS

收录：;EI(收录号：20253218947212);WOS:【SCI-EXPANDED(收录号:WOS:001545211500001)】；

基金：This work was supported by the research was supported by the Basic Science Center Program of the National Natural Science Foundation of China (No. T2288102), the Key Research Programme of Henan Province (221111520200), Clinical Medical Research Special Fund Project of Zhejiang Medical Association (2022ZYC-D13), Wenzhou major science and technology project (ZY2023010, ZY2024014), Wenzhou Basic Public Welfare Scientific Research Project (Y2023146), Zhejiang Provincial Natural Science Foundation of China under Grant No. TGY24E030007.

语种：英文

外文关键词：Biodegradable; elastic-memory function; poly(D, L-lactide-co-epsilon-caprolactone); ring-opening polymerization

摘要：Polylactic acid (PLA) is a biodegradable material for tissue engineering, while its mechanical fragility and uncontrollable biodegradability limit its further application in biomedical fields. In this study, a series of poly(D, L-lactide-co-epsilon-caprolactone) (PDLCL) gradient copolymers were synthesized through ring-opening polymerization by modulating the lactide/caprolactone (LA/CL) monomer ratio, which is expected to achieve excellent elasticity and controllable degradation properties. In particular, the introduction of 35% CL monomer into PLA gave PDLCL6535 copolymers with improved flexibility (elongation at break is 607.3 +/- 24.0%, 152 times that of PLA) with relatively high tensile strength (13.6 +/- 0.4 MPa), offering a good elastic-memory property (elastic recovery could reach 91.2%). Furthermore, the biodegradable rate and hydrophilicity of PDLCL copolymers improved with the CL content increase. In vitro biocompatibility evaluation indicated that the PDLCL materials had good biosafety and reached the level I, rendering PDLCL an ideal candidate for the development of medical devices, especially elastic film, and tubes.