文献类型：期刊文献

英文题名：A ligand-free, powerful, and practical method for methoxylation of unactivated aryl bromides by use of the CuCl/HCOOMe/MeONa/MeOH system

作者：Guo, Ying[1];Ji, Si-Zhe[2];Chen, Cheng[1];Liu, Hong-Wei[1];Zhao, Jian-Hong[1];Zheng, Yu-Lin[3];Ji, Ya-Fei[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China;[3]Shanghai New Asia Pharmaceut Co Ltd, Shanghai 201203, Peoples R China

年份：2015

卷号：41

期号：11

起止页码：8651

外文期刊名：RESEARCH ON CHEMICAL INTERMEDIATES

收录：;EI(收录号：20150300431697);WOS:【SCI-EXPANDED(收录号:WOS:000362896400043)】；

基金：The authors are grateful to the National Natural Science Foundation of China (project nos 21176074 and 21476074), the Research Fund for the Doctoral Program of Higher Education of China (project no. 20130074110009), and the Shandong Rongyuan Pharmaceutical Co. Ltd. for financial support.

语种：英文

外文关键词：Cu-catalysis; Unactivated aryl bromides; Methoxylation; Aryl methyl ethers; Recovery of pure MeOH

摘要：A ligand-free, powerful, and practical method for mono and polymethoxylation of unactivated aryl bromides has been developed; CuCl was used as catalyst, HCOOMe as cocatalyst, and methanolic MeONa as both nucleophile and solvent. This eco-friendly procedure is characterized by operational simplicity, inexpensive substrates (unactivated mono to polybromoarenes), full conversion, and direct recovery of pure MeOH.