文献类型：期刊文献

英文题名：Lipid-Stabilized Double Emulsions Generated in Planar Microfluidic Devices

作者：Kong, Lingling[1,3];Levin, Aviad[1];Toprakcioglu, Zenon[1];Xu, Yufan[1];Gang, Hongze[3];Ye, Ruqiang[3];Mu, Bo-Zhong[3,4];Knowles, Tuomas P. J.[1,2]

机构：[1]Univ Cambridge, Ctr Misfolding Dis, Dept Chem, Cambridge CB2 1EW, England;[2]Univ Cambridge, Cavendish Lab, Cambridge CB2 1EW, England;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai 200237, Peoples R China

年份：2020

卷号：36

期号：9

起止页码：2349

外文期刊名：LANGMUIR

收录：;EI(收录号：20201208327952);WOS:【SCI-EXPANDED(收录号:WOS:000519337400021)】；

基金：The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013) through the ERC grant PhysProt (agreement no 337969). We are grateful for financial support from the China Scholarships Council (CSC) (L.K.), the FEBS Long-Term Fellowship (A.L.), the Oppenheimer Early Career Fellowship (A.L.), the BBSR(T.P.J.K.), the Newman Foundation (T.PJ.K,), the Wellcome Trust (T.P.J.K.), and the Cambridge Centre for Misfolding Diseases (T.P.J.K., A.L., Z.T.).

语种：英文

外文关键词：Fluidic devices - Hydrophobicity - Emulsification - Micrometers - Ostwald ripening - Surface chemistry - Microfluidics

摘要：Microemulsions have found a wide range of applications exploiting their chemical and physical properties. Development of microfluidic-based approaches has allowed for the controlled production of highly monodispersed emulsions, including the formation of multiple and hierarchical emulsions. Conventional poly(dimethylsiloxane)-based microfluidic systems require tight spatial control over the surface chemistry when used for double emulsion generation, which can be challenging to achieve on the micrometer scale. Here, we present a two-dimensional device design, which can selectively be surface-treated in a straightforward manner and allows for the formation of uniform water/oil/water double emulsions by combining two distinct hydrophilic and hydrophobic surface properties. These surfaces are sufficiently separated in space to allow for imparting their functionalization without the requirement for lithographic approaches or complex flow control. We demonstrate that a mismatch between the wettability requirements of the continuous phase and the channel wall inherent in this approach can be tolerated over several hundreds of micrometers, opening up the possibility to use simple pressure-driven flows to achieve surface functionalization. The design architecture exhibits robust efficiency in emulsion generation while retaining simple device fabrication. We finally demonstrate the potential of this approach by generating water in oil in water emulsions with lipid molecules acting as surfactants.