文献类型：期刊文献

英文题名：Significantly improved production of Welan gum by Sphingomonas sp. WG through a novel quorum-sensing-interfering dipeptide cyclo (L-Pro-L-Phe)

作者：Zhu, Hu[1];Sun, Shi-wei[2];Li, Hui[3];Chang, Aiping[1];Liu, Yu-chen[3];Qian, Jin[4];Shen, Ya-ling[4]

机构：[1]Fujian Normal Univ, Fujian Prov Univ, Fujian Prov Key Lab Adv Mat Oriented Chem Engn, Coll Chem & Mat Sci,Engn Res Ctr Ind Biocatalysis, 32 Shangsan Rd, Fuzhou 350007, Fujian, Peoples R China;[2]Qingdao Univ, Sch Pharm, Dept Nat Med & Pharmacrognosy, 308 Ningxia Rd, Qingdao 266071, Peoples R China;[3]China Univ Petr East China, Ctr Bioengn & Biotechnol, 66 Changjiang West Rd, Qingdao 266580, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：126

起止页码：118

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;EI(收录号：20242616308024);WOS:【SCI-EXPANDED(收录号:WOS:000460710000014)】；

基金：This work was financially supported by the 863 Program (2015M020925), Natural Science Foundation of China (31800075 and U1805234), Minjiang Scholar (2013A13), Scientific Research Start-up Fund for High-Level Talents in Fujian Normal University (004828), Shandong Provincial Natural Science Foundation (ZR2015CL003), Fundamental Research Funds for the Central Universities (18CX02124A), and Partially Supported by Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

外文关键词：Quorum sensing; Cyclo(L-Pro-L-Phe); Welan gum

摘要：A variety of physiological functions such as exopolysaccharide synthesis, antibiotic production, and primary metabolism are tightly controlled by quorum sensing in microorganisms. In this study, a marine-derived bacterium Sphingomonas sp. WG was found to possess a cyclo(L-Pro-L-Phe)-mediated quorum sensing mechanism. The cyclo(L-Pro-L-Phe) produced by Sphingomonas sp. WG functions as a signalling molecule in this quorum sensing system. It is the first attempt to characterize cyclic dipeptides as quorum sensing signalling molecules in Sphingomonas sp. and the results effectively make the classical quorum sensing theory more perfect. Furthermore, the supplementation with isolated cyclo(L-Pro-L-Phe) resulted in a 15% increase in the production of welan gum secreted by Sphingomonas sp. WG in the submerged fermentation. The data presented in this study will provide evidences for exploring the role of cyclic dipeptides in regulating the production of welan gum. (C) 2019 Elsevier B.V. All rights reserved.