文献类型：期刊文献

英文题名：Carbon-mediated synthesis of shape-controllable manganese phosphate as nanozymes for modulation of superoxide anions in HeLa cells

作者：Cai, Xuan[1];Wang, Zhenxing[1];Zhang, Huanhuan[1];Li, Yufei[1];Chen, Kaicha[1];Zhao, Hongli[1];Lan, Minbo[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：7

期号：3

起止页码：401

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20190406403415);WOS:【SCI-EXPANDED(收录号:WOS:000457595000005)】；

基金：This research was financially supported by the Science and Technology Commission of Shanghai Municipality (STCSM, No. 16520710800) and the Fundamental Research Funds for the Central Universities (No. 222201817022).

语种：英文

外文关键词：Cancer cells - Electrochemical sensors - Controlled drug delivery - Lanthanum compounds - Phosphates - Carbon - Transition metals

摘要：Transition metal phosphates have shown great potential as nanozymes for selective detection of reactive oxygen species (ROS), but its application has been hindered by the complicated synthesis and difficulty in shape and size control. Herein, we present a facile method to fabricate transition metal phosphates by using hollow carbon structures as substrates. Manganese phosphate is a typical Nanozyme used in this design and the shape and size of the Mn-x(PO4) y layer can be efficiently controlled by altering the carbon substrates. Characterization demonstrated that Mn-x(PO4) y layer modified hollow carbon sphere (Mn-MPSA-HCS) and hollow carbon cubic (Mn-MPSA-HCC) were successfully prepared and used as nanozymes for superoxide detection. The established electrochemical sensor was employed in the online monitoring of drug stimulated superoxide anions released from cancer cells. This method can be adapted as a general way to prepare transition metal phosphate layers with various controllable shapes and sizes as nanozymes for different uses in the future.