文献类型：期刊文献

英文题名：Rational Design of GO-Modified Fe3O4/SiO2 Nanoparticles with Combined Rhenium-188 and Gambogic Acid for Magnetic Target Therapy

作者：Yang, Yuxiang[1,2];Liu, Yicheng[1];Cheng, Chao[3];Shi, Haowei[1];Yang, Huan[1];Yuan, Hongming[4];Ni, Chaoying[2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA;[3]Second Mil Med Univ, Changhai Hosp, Dept Nucl Med, Shanghai 200237, Peoples R China;[4]Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Jilin, Peoples R China

年份：2017

卷号：9

期号：34

起止页码：28195

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20173604127019);WOS:【SCI-EXPANDED(收录号:WOS:000409395500009)】；

基金：The authors are grateful to the financial support from the National Natural Science Foundation of China (Grant Nos. 20971043 and 20577101) and to Xiang-nong Liu, at the Analysis and Testing Center, Yangzhou University, for help in sample characterization.

语种：英文

外文关键词：europium oxychloride dopant; graphene oxide modified; multifunctional; radionuclide imaging; magnetic target biodistribution; PEI-GO convergence effect

摘要：Peanut,like magnetic-fluorescent Fe3O4/SiO2 nanoparticles, with an effective dynamic diameter of 180 nm, were synthesized via EuO+ doping and, coupling of two-Fe3O4 cores and reassembling through the solvothermal process. Spherical pure Fe3O4/SiO2 nanoparticles with an effective dynamic diameter of 230 nm were also prepared for comparison. We designed graphene oxide (GO)-modified core shell FeO4/SiO2 nanoparticles as a nanocarrier for loading gambogic acid (GA) following labeling with radioisotope rhenium-188. We also performed GA loading and releasing on GA-loaded magnetic nanoparticles, in vivo biodistribution, and magnetic drug targeting therapy experiments. Results indicated that the GA-loaded magnetic nanoparticles demonstrate a clear pH-dependent drug release behavior, having a higher release rate in acidic environments. The in vivo biodistribution of the magnetic nanoparticles has morphologic dependency, and the peanutlike nanoparticles (PN-Fe3O4) tend to accumulate more in the spleen, lung, and liver than in the spherical nanoparticles (S-Fe3O4). The targeted therapy showed a higher efficacy of PN-Fe3O4 in inhibiting tumor cell growth than the nontargeted therapy. The polyethyleneimine (PEI) grafting of PN-Fe3O4 with amide bond was also designed to find an effective active targeting antitumor agent considering the fact that the PEI GO conjugate has a higher GA load efficiency and the convergence effect.