文献类型：期刊文献

中文题名：Novel antibacterial cellulose diacetate-based composite 3D scaffold as potential wound dressing

作者：Wencheng Liang[1,3];Mingli Jiang[2];Junyong Zhang[3];Xiaoming Dou[1];Yan Zhou[2];Yun Jiang[5];Li Zhao[4];Meidong Lang[3]

机构：[1]Center of Photonics&Bio-Medical Diagnosis,School of Science,East China University of Science and Technology,Shanghai 200237,China;[2]State Key Laboratory of Bioreactor Engineering,School of Biotechnology,East China University of Science and Technology,Shanghai 200237,China;[3]Shanghai Key Laboratory of Advanced Polymeric Materials,Key Laboratory for Ultrafine Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;[4]State Key Laboratory of Bioreactor Engineering,New World Institute of Biotechnology,East China University of Science and Technology,Shanghai 200237,China;[5]The Library of Zhejiang University of Technology,Zhejiang University of Technology,Hangzhou 310023,China

年份：2021

期号：30

起止页码：225

中文期刊名：Journal of Materials Science & Technology

外文期刊名：材料科学技术（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；PubMed;

基金：financially supported by the National Key Research and Development Program(No.2016YFC1100703)。

语种：英文

中文关键词：Cellulose diacetate;Electrospinning;3D scaffold;Wound dressing

摘要：In this work,novel antibacterial cellulose diacetate/poly(ethylenimine)/hyaluronic acid(CDA/PEI/HA)composite three-dimension(3D)scaffolds were prepared through electrospinning and post-processing.Firstly,CDA/PEI 2D composite nanofiber membranes were prepared by electrospinning,and then the CDA/PEI/HA 3D composite scaffolds were fabricated by post-processing and freeze-drying of CDA/PEI membranes.In particular,HA was added to improve the biocompatibility of composite scaffolds.Compared with CDA/PEI scaffolds,CDA/PEI/HA composite scaffolds showed higher water absorbing rate,higher water retention rate and higher mechanical strength.Moreover,CDA/PEI/HA composite scaffolds with abundant positive charge were benefit for improving antibacterial activity.CDA/PEI/HA scaffolds with biology function of HA were benefit for improving hemocompatibility and cell proliferation of CDA/PEI scaffolds.In summary,antibacterial CDA/PEI/HA scaffolds could protect wound from bacterial infection,improve cellular behavior and accelerate wound healing.Thus,CDA/PEI/HA scaffolds could be potential application for wound dressing.