文献类型：期刊文献

英文题名：Antitumor and immunomodulatory activities of a polysaccharide from Artemisia argyi

作者：Bao, Xiaoli[1]; Yuan, Huihui[2]; Wang, Chengzhong[1]; Liu, Jinjin[1]; Lan, Minbo[1,3]

机构：[1] Shanghai Key Laboratory of Functional Materials Chemistry, Research Centre of Analysis and Test, East China University of Science and Technology, Shanghai 200237, China; [2] Institute of Applied Chemistry, East China University of Science and Technology, Shanghai 200237, China; [3] State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China

年份：2013

卷号：98

期号：1

起止页码：1236

外文期刊名：Carbohydrate Polymers

收录：EI(收录号：20134216848345)

语种：英文

外文关键词：Mammals

摘要：A water-soluble polysaccharide (FAAP-02), composed of N-acetyl-d- glucosamine, glucose, mannose, galactose, rhamnose arabinose, xylose and ribose, with an average molecular weight of 5169 Da, was isolated from Artemisia argyi. The antitumor and immunomodulatory activities of FAAP-02 were evaluated in Sarcoma 180 (S180) tumor-bearing mice by intraperitoneal administration. As a result, FAAP-02 significantly inhibited the growth of the S180 transplanted tumors and prolonged the survival time of the tumor-bearing mice. Moreover, FAAP-02 could obviously increase the thymus and spleen indices, the levels of serum Interleukin 2 (IL-2), Interleukin 6 (IL-6), Interleukin 12 (IL-12) and tumor necrosis factor- α (TNF-α) and the expression of CD4+ and CD8+ splenic T lymphocytes which were suppressed by the transplanted tumor or/and 5-fluorouracil (5-FU) in the mice. These results indicated that the antitumor activity of FAAP-02 might be associated with its immunostimulatory effects. ? 2013 Elsevier Ltd. All rights reserved.