文献类型：期刊文献

英文题名：An Inspection into Multifarious Ways to Synthesize Poly(Amino Acid)s

作者：Zheng, Botuo[1,2];Bai, Tianwen[1];Tao, Xinfeng[3];Ling, Jun[1]

机构：[1]Zhejiang Univ, Dept Polymer Sci & Engn, MOE, Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China;[2]Fujian Normal Univ, Coll Chem & Mat Sci, Fujian Key Lab Polymer Sci, Fuzhou 350007, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China

年份：2021

卷号：42

期号：22

外文期刊名：MACROMOLECULAR RAPID COMMUNICATIONS

收录：;EI(收录号：20214211021911);WOS:【SCI-EXPANDED(收录号:WOS:000706873400001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Grant Nos. 21901073 and 21674091) and sponsored by "Chenguang Program" (Program No. 18CG32) supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission.

语种：英文

外文关键词：N-carboxyanhydrides; N-phenoxycarbonyl amino acids; N-thiocarboxyanhydrides; polypeptides; polypeptoids

摘要：Poly(alpha-amino acid)s (PAAs) attract growing attention due to their essential role in the application as biomaterials. To synthesize PAAs with desired structures and properties, scientists have developed various synthetic techniques with respective advantages. Here, different approaches to preparing PAAs are inspected. Basic features and recent progresses of these methods are summarized, including polymerizations of amino acid N-carboxyanhydrides (NCAs), amino acid N-thiocarboxyanhydrides (NTAs), and N-phenoxycarbonyl amino acids (NPCs), as well as other synthetic routes. NCA is the most classical monomer to prepare PAAs with high molecular weights (MWs). NTA polymerizations are promising alternative pathways to produce PAAs, which can tolerate nucleophiles including alcohols, mercaptans, carboxyl acids, and water. By various techniques including choosing appropriate solvents or using organic acids as promoters, NTAs polymerize to produce polypeptoids and polypeptides with narrow dispersities and designed MWs up to 55.0 and 57.0 kg mol(-1), respectively. NPC polymerizations are phosgene-free ways to synthesize polypeptides and polypeptoids. For the future prospects, detail investigations into polymerization mechanisms of NTA and NPC are expected. The synthesis of PAAs with designed topologies and assembly structures is another intriguing topic. The advantages and unsettled problems in various synthetic ways are discussed for readers to choose appropriate approaches for PAAs.