文献类型：期刊文献

英文题名：Characterization and release kinetics of liposomes inserted by pH-responsive bola-polymer

作者：Hao, Weiju[1,2];Xia, Tian[1,2];Shang, Yazhuo[1,2];Xu, Shouhong[1,2];Liu, Honglai[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China

年份：2016

卷号：294

期号：7

起止页码：1107

外文期刊名：COLLOID AND POLYMER SCIENCE

收录：;EI(收录号：20161702281636);WOS:【SCI-EXPANDED(收录号:WOS:000378567100002)】；

基金：Financial support for this work is provided by the National Natural Science Foundation of China (no. 21276074), the 111 Project of China (no. B08021), and the Fundamental Research Funds for the Centre Universities of China.

语种：英文

外文关键词：Liposome; Bola-polymer; pH responsibility; Controlled release; Smart drug delivery

摘要：One important thing in tumor chemotherapy is to develop the targeting, precise timing, and quantitative drug delivery/release system. According to the weak acid of tumor extracellular environment, a pH-sensitive bola-type triblock copolymer (PEG(m)-PDPA(n)-PEG(m)) was synthesized and mixed with phospholipid to form functional hybrid liposomes (liposome@Bola). When compared to pure liposome, the stability of the liposome@Bola was enhanced greatly and the drug leakage was inhibited at pH 7.4. However, under pH 6.0, the drug released quickly through the nanopores on the lipid bilayer created by the escape of copolymers. Under a strongly acidic environment, the drug release of liposome@Bola could be blocked again due to the coverage of free copolymers. The kinetic curves of drug release had been modeled by using some frequently used models. It was found that the release of liposome@Bola under pH 6.0 was biphasic with a slow release by means of membrane permeation and a rapid second phase which was released through nanopores on liposome membrane. The results indicated that the pH-responsive liposome@Bola could be expected to be a good potential in controllable drug delivery system.