文献类型：期刊文献

英文题名：Gold(I)-Catalyzed Selective Heterocyclization of Propargylic Thioureas: Mechanistic Study of Competitive Gold-Activation Mode

作者：Jiang, Yu[1,2];Wei, Yin[3];Tang, Xiang-Ying[3];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

年份：2015

卷号：21

期号：21

起止页码：7675

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20151900836071);WOS:【SCI-EXPANDED(收录号:WOS:000354204300005)，CCR-EXPANDED(收录号:WOS:000354204300005)】；

基金：We are grateful for the financial support from the National Basic Research Program of China (973-2015CB856603), the National Natural Science Foundation of China (20472096, 21372241, 21361140350, 20672127, 21421091, 21372250, 21121062, 21302203 and 20732008).

语种：英文

外文关键词：gold; heterocycles; homogeneous catalysis; reaction mechanisms; thioureas

摘要：A new selective gold(I)-catalyzed intramolecular heterocyclization of propargylic thioureas has been developed, efficiently affording two kinds of cycloadducts in moderate to excellent yields with a broad substrate scope. Further mechanistic investigations indicate that competitive different gold activation modes feature in these cyclization processes. Kinetic experiments reveal that the gold activation mode is influenced by the ligand of the gold catalyst and the reaction conditions.