文献类型：期刊文献

英文题名：Bidirectional ROS Modulation for Programmed Anti-Infective and Anti-Inflammatory Therapy With Au-Cu2O/MXene Nanocomposite

作者：Zhang, Min[1];Hu, Kami[1,2];Zhu, Liuyuan[1];Ding, Rui[1];Hou, Ying[1];Mou, Junjie[1];Xia, Haoming[1];Lin, Yihe[2];Zheng, Purui[2];Zhan, Lingnv[3];Fang, Haiping[1];He, Hui[2];Zeng, Chunhua[4];Huang, Yingying[1];Chen, Ruoyang[1]

机构：[1]East China Univ Sci & Technol, Sch Phys, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[2]Zhejiang Sci Tech Univ, Fash Design Coll Lstituto Marangoni, Sch Int Educ, Linping, Zhejiang, Peoples R China;[3]Shanghai Xuhui Dist Stomatol Hosp, Shanghai, Peoples R China;[4]Kunming Univ Sci & Technol, Fac Sci, Kunming, Yunan, Peoples R China

年份：2026

外文期刊名：SMALL

收录：;EI(收录号：20263421326969);Scopus(收录号：2-s2.0-105047620486);WOS:【SCI-EXPANDED(收录号:WOS:001850559100001)】；

基金：This work was supported by Shanghai Pujiang Program (No. 23PJ1401800), the Fundamental Research Funds of Zhejiang Sci-Tech University (No. 26192182-Y); China National University Student Innovation & Entrepreneurship Development Program (No. 11332932662601 and 11332932662610), the National Natural Science Foundation of China (12435001), Shanghai Science and Technology Innovation Action Plan (No. 23JC1401400) and the Fundamental Research Funds for the Central Universities of East China University of Science and Technology.

语种：英文

外文关键词：antibacterial activity; cuprous oxide nanostructure; edge capping of gold; reactive oxygen

摘要：Chronic bacterial infections pose a therapeutic challenge in eliminating bacteria while suppressing inflammation. Conventional antibiotics are often limited by drug resistance and poor biofilm penetration, contributing to a global health threat of antibiotic misuse. Reactive oxygen species (ROS) modulation offers a promising alternative, yet requires precise balance: insufficient ROS compromises antibacterial efficacy, but excess exacerbates inflammation. Here, we present a bidirectional ROS-regulation strategy for programmed antibacterial and anti-inflammatory therapy using Au-edged cuprous oxide (Cu2O) nanocubes on MXene (Au-Cu2O/MXene). Under near-infrared (NIR) irradiation, this nanocomposite induces moderate ROS, eliminating >99% of planktonic bacteria and >97% of mature biofilms. After cessation of NIR irradiation, the nanocomposite itself switches to scavenge the residual excessive ROS in the inflammatory microenvironment, which alleviates oxidative stress. Our skin wound infection model further demonstrates that Au-Cu2O/MXene markedly reduces bacterial burden, suppresses inflammatory responses, and accelerates wound closure. Theoretical computations reveal that Au-capping weakens O(2)adsorption through weak O 2p-Au 5d orbital hybridization and hinders photogenerated electron transfer with high work function, suppressing ROS overproduction; it also lowers the free energy barrier for H2O/O(2 )desorption, promoting ROS decomposition. This work offers an effective antibiotic-free immunomodulation strategy for programmed biofilm eradication, infected wound repair, and inflammation suppression via context-dependent ROS modulation.