文献类型：期刊文献

英文题名：Amphipathic poly-β-peptides for intracellular protein delivery

作者：Ren, Qianyi[1];Chen, Qi[2];Ren, Lanfang[1];Cao, Chuntao[2];Liu, Runhui[2];Cheng, Yiyun[1]

机构：[1]East China Normal Univ, Shanghai Frontiers Sci Ctr Genome Editing & Cell, Sch Life Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat,State Key Lab Bioreactor Engn, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine, Shanghai 200237, Peoples R China

年份：2022

卷号：58

期号：27

起止页码：4320

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20221511940339);WOS:【SCI-EXPANDED(收录号:WOS:000769613600001)】；

基金：We appreciate support from the National Natural Science Foundation of China (22135002, 21861162010) and the Basic Research Program of Science and Technology Commission of Shanghai Municipality (21JC1401800) for this work. We also acknowledge the support from the Flow Cytometry Core Facility at ECNU.

语种：英文

摘要：A series of amphipathic poly-beta-peptides are designed for intracellular protein delivery. The poly-beta-peptides with higher molecular weight and hydrophobic contents exhibit higher protein loading and superior delivery efficiency. The lead material efficiently delivers proteins into cells with reserved bioactivity.