文献类型：期刊文献

中文题名：两种螯合树脂用于板蓝根提取液脱重金属的比较

英文题名：Study on Two Chelating Resins Removing Heavy Metal from Extracts of Radix Isatidis

作者：魏继新[1];张立国[1];倪力军[1]

机构：[1]华东理工大学化学与分子工程学院,上海200237

年份：2007

卷号：18

期号：2

起止页码：139

中文期刊名：中药新药与临床药理

外文期刊名：Traditional Chinese Drug Research and Clinical Pharmacology

收录：CSTPCD;;CSCD:【CSCD_E2011_2012】；

基金："十五"国家科技攻关项目(2004BA721A45)

语种：中文

中文关键词：螯合树脂;板蓝根;重金属;HPLC

外文关键词：Chelating resins; Radix Isatidis; Heavy metals; HPLC

摘要：目的研究两种螯合树脂A和B用于脱除板蓝根提取液中重金属离子的可行性。方法在工业模式中药自控提取平台上进行脱重金属实验,以干膏得率、HPLC图谱相似度和重金属脱除率为考察指标,比较两种树脂对有关指标的影响。结果脱重金属后干膏得率损失低于7%,各批经过脱重金属单元所得干膏的重金属含量均低于国家限量。应用树脂A脱除重金属前后干膏的HPLC图谱相似度大于0.97,应用树脂B脱除重金属前后干膏的HPLC图谱相似度很低。结论树脂A较适合脱除板蓝根提取液中的重金属。
Objective To study the feasibility of chelating resins A and B removing heavy metals from the extracts of Radix Isatidis. Methods Heavymetal Removal experiment was performed on automatic control platform in industry mode. With dry ointment yield, comparability of HPLC and removal rate of heavy metals as the indexes, the effects of two kinds of Chelating resins in removing heavy metal were compared. Results After finishing heavy metal removal step, the loss rate of the dry - extract was lower than 7 %, and the heavy metal contents in dry - extract were lower than national limits. HPLC similarity of the extracts before and after removing heavy metals by resin A was higher than 0.97, but that by resin B was very low. Conclusion Chelating resin A is suitable for removing heavy metals from extracts of Radix Isatidis.