文献类型：期刊文献

中文题名：Application of photopharmacology in agrochemicals

作者：Wen Fu[1];Zhong Li[1,2];Xusheng Shao[1,2,3,4]

机构：[1]Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology,Shanghai,200237,China;[2]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai,200237,China;[3]Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism,School of Pharmacy,East China University of Science and Technology,Shanghai,200237,China;[4]Engineering Research Center of Pharmaceutical Process Chemistry,Ministry of Education,School of Pharmacy,East China University of Science and Technology,Shanghai,200237,China

年份：2023

卷号：2

期号：2

起止页码：142

中文期刊名：Advanced Agrochem

外文期刊名：现代农业化学（英文）

基金：the financial support by the National Natural Science Foundation of China(No.21877039,No.32072441);National Key Research and Development Program of China(2018YFD0200100);Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-02-E00037).

语种：英文

中文关键词：Photopharmacology;Agrochemicals;Photochromic ligands;Optical control;Ligand-receptor interactions

摘要：Photopharmacology is a novel technology in drug design that aims at solving poor drug selectivity.This technology is currently in the proof-of-concept phase and relies on the photoactivation or inactivation of photochromic ligands(PCLs)to regulate biological functions and living organisms.As potential molecular tools in future agriculture 4.0,the photochromic pesticides are effective in optical control of receptors,ion channels,living behaviors,and enzymes,which displays an innovative way of pesticide discovery.In this review,we highlight the progresses of the photoisomerized insecticides and fungicides.By integrating photoswitches,such as azobenzenes and diarylethenes,into pesticide molecules,several PCLs were developed for optical regulation of important insect or fungi targets in vivo,including GABARs,RyRs,nAChRs,SURs,sodium channels,GluCls,and SDH.The results are highly significant in revealing interactions of agrochemicals with their targets,biological functions,and living behaviors,and provide powerful toolkits in understanding ligand-receptor interactions.Moreover,there is a growing demand for a diverse range of PCLs,particularly those that are sensitive to red and NIR light or sunlight,for actual field use in agriculture.We envision that this particular mode of pesticide discovery is of great promise for overcoming the challenges posed by the improper use of agrochemicals.